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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Bacteremia
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Accession:DOID:9005036 term browser browse the term
Definition:The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Synonyms:exact_synonym: BACTS1;   BACTS2;   Bacteremias;   bacteriemia
 narrow_synonym: non-typhoidal Salmonella bacteremia
 related_synonym: Bacteremia, Resistance To;   bacteremia, susceptibility to, 1;   bacteremia, susceptibility to, 2
 primary_id: MESH:D016470
 alt_id: OMIM:614382;   OMIM:614383
 xref: EFO:0003033;   EFO:0009087

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show annotations for term's descendants           Sort by:
Bacteremia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO associated with Febrile Neutropenia;protein:increased expression:serum (human) RGD PMID:22584776 RGD:11528568 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta ISO associated with alcohol use disorder;mRNA:increased expression:bone marrow (mouse) RGD PMID:28784931 RGD:40903040 NCBI chr 2:13,780,538...13,782,639
Ensembl chr 2:13,781,160...13,782,194 		JBrowse link
G CFH complement factor H ISO associated with Meningococcal Infections; RGD PMID:22104107 RGD:7364945 NCBI chr25:32,557,697...32,744,763 JBrowse link
G CISH cytokine inducible SH2 containing protein susceptibility ISO ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2 OMIM
ClinVar		 PMID:20484391 NCBI chr22:11,993,212...11,998,625
Ensembl chr22:11,993,242...11,995,375 		JBrowse link
G CPB2 carboxypeptidase B2 ISO protein:decreased activity:plasma RGD PMID:17911187 RGD:2313646 NCBI chr 3:24,108,854...24,161,669
Ensembl chr 3:24,109,416...24,161,408 		JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum: RGD PMID:18443549 RGD:9491402 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
G CSF2 colony stimulating factor 2 treatment ISO RGD PMID:2192004 RGD:10449532 NCBI chr23:34,906,987...34,911,252
Ensembl chr23:34,908,911...34,911,140 		JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa ISO associated with Pneumonia;DNA:SNP: :p.H131R (rs1801274) (human) RGD PMID:21317643 RGD:5147986 NCBI chr20:2,480,710...2,512,429 JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase severity ISO RGD PMID:11565076 RGD:5508478 NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO mRNA:increased expression:lung,thymus,spleen: RGD PMID:24891762 RGD:11354979 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IL17A interleukin 17A ISO associated with Respiratory Distress Syndrome, Adult; protein:increased expression:serum RGD PMID:21062445 RGD:5128683 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL27 interleukin 27 ISO protein:increased expression:blood serum (human) RGD PMID:26514771 RGD:126790515 NCBI chr 5:26,348,559...26,358,028
Ensembl chr 5:26,348,848...26,356,360 		JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 ISO protein:increased expression:liver, serum RGD PMID:33348064 RGD:40907057 NCBI chr22:14,194,979...14,216,180
Ensembl chr22:14,195,701...14,213,603 		JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 ISO ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2 ClinVar PMID:20484391 NCBI chr22:11,998,774...12,036,477 JBrowse link
G MBL2 mannose binding lectin 2 treatment ISO associated with Multiple Myeloma:DNA:polymorphism:exon: RGD PMID:16953214 RGD:11530047 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 severity ISO associated with Staphylococcal Infections; RGD PMID:24086711 RGD:13204726 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:1430592 NCBI chr 8:40,164,391...40,196,627
Ensembl chr 8:40,163,891...40,196,555 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor severity ISO RGD PMID:21332843 RGD:6483799 NCBI chr 6:37,161,957...37,191,867 JBrowse link
G SERPINC1 serpin family C member 1 treatment ISO RGD PMID:2679067 RGD:11035251 NCBI chr25:55,271,823...55,289,855 JBrowse link
G SOD2 superoxide dismutase 2 ISO mRNA:increased expression:liver: RGD PMID:24253037 RGD:26923958 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974 		JBrowse link
G TIRAP TIR domain containing adaptor protein ISO ClinVar Annotator: match by term: Bacteremia, susceptibility to, 1 OMIM
ClinVar		 PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18180796 RGD:4144194 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
Endotoxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO mRNA:decreased expression:liver (rat) RGD PMID:26977098 RGD:11041000 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 ISO RGD PMID:9828229 RGD:1598596 NCBI chr10:54,458,283...54,575,943
Ensembl chr10:54,459,377...54,575,059 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO RGD PMID:16572733 RGD:1598611 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 ISO RGD PMID:17285300 RGD:2301914 NCBI chr 1:47,494,861...47,578,818
Ensembl chr 1:47,494,959...47,578,882 		JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) ISO RGD PMID:17657467 RGD:5688055 NCBI chr28:12,328,304...12,335,302
Ensembl chr28:12,331,039...12,335,076 		JBrowse link
G ACTC1 actin alpha cardiac muscle 1 ISO RGD PMID:11680626 RGD:1598729 NCBI chr26:48,105,271...48,110,670
Ensembl chr26:48,105,216...48,110,896 		JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO protein:increased expression:plasma, spleen RGD PMID:23025351 RGD:9681752 NCBI chr 2:65,376,288...65,385,398
Ensembl chr 2:65,376,310...65,385,918 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO associated with Obesity RGD PMID:23838384 RGD:8695926 NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391 		JBrowse link
G ADIPOR2 adiponectin receptor 2 severity ISO associated with obesity;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chr11:1,802,694...1,836,703
Ensembl chr11:1,738,026...1,837,060 		JBrowse link
G ADRA2A adrenoceptor alpha 2A onset ISO mRNA:increased expression:spleen RGD PMID:20302880 RGD:6480487 NCBI chr 9:104,015,577...104,019,364
Ensembl chr 9:104,016,580...104,017,932 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO protein:decreased expression:kidney RGD PMID:16725227 RGD:6903849
G AHR aryl hydrocarbon receptor severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:22824368 RGD:38676479 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G ALDOA aldolase, fructose-bisphosphate A ISO RGD PMID:16930621 RGD:1599054 Ensembl chr 5:26,588,868...26,592,112 JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15328337 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331 		JBrowse link
G APOA1 apolipoprotein A1 treatment ISO RGD PMID:18593575 PMID:23227448 RGD:7241573 RGD:7241868 NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609 		JBrowse link
G APOB apolipoprotein B ISO RGD PMID:16719989 RGD:1599165 NCBI chr14:86,624,209...86,669,175
Ensembl chr14:86,624,332...86,668,704 		JBrowse link
G APOE apolipoprotein E ISO rat model treated with human protein RGD PMID:9153287 RGD:6904216 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G ASL argininosuccinate lyase ISO RGD PMID:10652239 RGD:1599265 NCBI chr28:1,782,434...1,800,581
Ensembl chr28:1,782,553...1,802,517 		JBrowse link
G ASS1 argininosuccinate synthase 1 ISO RGD PMID:10652239 RGD:1599265 NCBI chr12:7,643,484...7,701,334 JBrowse link
G ATF2 activating transcription factor 2 treatment ISO protein:increased expression, increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:10047418 RGD:5135029 NCBI chr10:60,644,623...60,734,465
Ensembl chr10:60,644,635...60,734,475 		JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr18:34,815,924...34,828,052
Ensembl chr18:34,816,027...34,830,924 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 6:42,186,028...42,193,105 JBrowse link
G BCHE butyrylcholinesterase ISO RGD PMID:17657467 RGD:5688055 NCBI chr15:23,708,121...23,778,027
Ensembl chr15:23,708,155...23,778,286 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO mRNA:decreased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G C5AR1 complement C5a receptor 1 ISO mRNA:increased expression:lung RGD PMID:9272704 RGD:70679 NCBI chr 6:40,633,540...40,651,839
Ensembl chr 6:40,633,448...40,652,845 		JBrowse link
G CASP1 caspase 1 ISO RGD PMID:17384935 RGD:2315892 NCBI chr 1:96,389,697...96,400,610
Ensembl chr 1:96,389,657...96,400,849 		JBrowse link
G CASP3 caspase 3 ISO mRNA:increased expression:diaphragm RGD PMID:23940949 RGD:10054120 NCBI chr 7:130,589,592...130,610,845
Ensembl chr 7:130,591,166...130,610,899 		JBrowse link
G CASP7 caspase 7 ISO RGD PMID:19168786 RGD:5684539 NCBI chr 9:106,558,291...106,607,662
Ensembl chr 9:106,559,445...106,607,663 		JBrowse link
G CASP9 caspase 9 treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:plasma RGD PMID:19060786 RGD:2307004 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:plasma RGD PMID:16215387 RGD:2307171 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:17016504 RGD:5688178 NCBI chr22:7,634,205...7,641,380 JBrowse link
G CD14 CD14 molecule ISO protein:increased expression:liver, endothelial cell of sinusoid RGD PMID:12046090 RGD:724637 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CD40 CD40 molecule ISO protein:decreased nitrosylation:macrophage RGD PMID:20473113 RGD:5490974 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta treatment ISO RGD PMID:14659593 PMID:15192048 RGD:1625687 RGD:40903034 NCBI chr 2:13,780,538...13,782,639
Ensembl chr 2:13,781,160...13,782,194 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr10:96,267,890...96,392,393
Ensembl chr10:96,267,889...96,392,206 		JBrowse link
G CS citrate synthase ISO protein:increased expression:gastrocnemius RGD PMID:25674200 RGD:329337350 NCBI chr11:52,224,667...52,253,552
Ensembl chr11:52,222,724...52,253,307 		JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO RGD PMID:9514298 RGD:11039535 NCBI chr16:66,162,814...66,166,192
Ensembl chr16:66,163,681...66,165,172 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900
Ensembl chr 7:22,569,355...22,569,900 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO mRNA:increased expression:multiple organs RGD PMID:9766630 RGD:5135254 NCBI chr 7:22,291,949...22,294,191
Ensembl chr 7:22,292,045...22,294,207 		JBrowse link
G EDN1 endothelin 1 ISO mRNA, protein:increased expression:liver (rat) RGD PMID:11206318 RGD:8662297 NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198 		JBrowse link
G EP300 E1A binding protein p300 ISO associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:19154430 RGD:5688360 NCBI chr 8:25,603,668...25,659,232
Ensembl chr 8:25,603,735...25,659,345 		JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:23214195 RGD:10400903 NCBI chr28:12,487,222...12,491,986
Ensembl chr28:12,489,766...12,491,908 		JBrowse link
G F12 coagulation factor XII ISO RGD PMID:11092686 RGD:7394782 NCBI chr23:79,414,074...79,438,896
Ensembl chr23:79,414,225...79,432,298 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO associated with Protein C Deficiency RGD PMID:8956768 PMID:20858853 PMID:21396682 RGD:11340208 RGD:11341685 RGD:5147765 NCBI chr20:38,726,690...38,738,457
Ensembl chr20:38,726,798...38,739,408 		JBrowse link
G F5 coagulation factor V ISO RGD PMID:11092686 RGD:7394782 NCBI chr25:59,465,610...59,539,022
Ensembl chr25:59,466,378...59,538,872 		JBrowse link
G F7 coagulation factor VII treatment ISO RGD PMID:11092686 PMID:16378835 RGD:11041650 RGD:7394782 NCBI chr 3:91,109,864...91,122,707
Ensembl chr 3:91,110,380...91,123,327 		JBrowse link
G F8 coagulation factor VIII ISO RGD PMID:11092686 RGD:7394782 NCBI chr  X:129,090,140...129,315,343
Ensembl chr  X:129,088,611...129,312,909 		JBrowse link
G FGA fibrinogen alpha chain treatment ISO RGD PMID:19295478 RGD:11040925 NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405 		JBrowse link
G FOXP3 forkhead box P3 ISO protein:increased expression:intestinal mucosa RGD PMID:19998507 RGD:38455980 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G GCH1 GTP cyclohydrolase 1 treatment ISO mRNA:increased expression:lung
associated with liver cirrhosis		 RGD PMID:9388472 PMID:14647062 PMID:16845913 RGD:329961576 RGD:401700399 RGD:401793756 NCBI chr24:32,029,997...32,079,656
Ensembl chr24:32,027,648...32,079,490 		JBrowse link
G GFER growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chr 5:1,880,025...1,886,829
Ensembl chr 5:1,879,968...1,883,696 		JBrowse link
G GHR growth hormone receptor ISO mRNA:decreased expression:liver RGD PMID:12217886 PMID:12654216 RGD:2307380 RGD:625688 NCBI chr 4:41,171,038...41,464,474
Ensembl chr 4:41,285,712...41,464,666 		JBrowse link
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:25514429 RGD:401717525 NCBI chr 8:138,716,802...138,721,421
Ensembl chr 8:138,718,767...138,721,251 		JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:25469663 RGD:10401928 NCBI chr 8:28,778,713...28,851,907 JBrowse link
G HMGB1 high mobility group box 1 ISO protein:increased expression:heart, serum RGD PMID:18503231 RGD:10402065 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:21396999 RGD:10755715 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G HSF1 heat shock transcription factor 1 treatment ISO RGD PMID:25571843 RGD:10402404 NCBI chr 8:138,503,836...138,529,562
Ensembl chr 8:138,503,831...138,529,165 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr23:41,230,675...41,251,177
Ensembl chr23:41,231,364...41,251,150 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:medulla oblongata		 CTD
RGD		 PMID:16675490 PMID:16741687 RGD:1624232 NCBI chr10:83,003,266...83,017,397
Ensembl chr10:83,003,717...83,017,363 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (rat) RGD PMID:19776691 RGD:4145502 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:24930766 PMID:28077574 RGD:39939032 RGD:39939117 NCBI chr 8:37,930,910...37,950,790
Ensembl chr 8:37,930,562...37,946,505 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 ISO RGD PMID:24930766 RGD:39939032 NCBI chr 8:37,951,810...38,027,689
Ensembl chr 8:37,959,078...38,027,632 		JBrowse link
G IFNG interferon gamma ISO protein:increased expression:serum: RGD PMID:9195172 RGD:10755747 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA, protein:decreased expression:liver, serum RGD PMID:12217886 PMID:18492809 RGD:10402757 RGD:625688 NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308 		JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit ISO RGD PMID:12217886 RGD:625688 NCBI chr 5:1,698,787...1,704,205
Ensembl chr 5:1,698,978...1,701,972 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 ISO RGD PMID:12217886 RGD:625688 NCBI chr21:12,932,727...12,939,078
Ensembl chr21:12,932,732...12,937,891 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO mRNA, protein:decreased expression:liver, serum RGD PMID:18492809 RGD:10402757 NCBI chr21:12,905,309...12,914,199
Ensembl chr21:12,905,280...12,914,205 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 ISO RGD PMID:12217886 RGD:625688 NCBI chr10:102,510,939...102,531,710
Ensembl chr10:102,510,897...102,531,724 		JBrowse link
G IL10 interleukin 10 treatment ISO protein:increased expression:plasma RGD PMID:19302852 PMID:27943364 PMID:28664613 RGD:14975137 RGD:14975170 RGD:2311055 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL13 interleukin 13 treatment ISO RGD PMID:10674721 RGD:8549626 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL1A interleukin 1 alpha ISO protein:increased expression:plasma RGD PMID:9636192 PMID:22426124 RGD:6907109 RGD:7794786 NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:plasma RGD PMID:17201737 RGD:1626625 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO mRNA:increased expression:lung, spleen, liver (rat) RGD PMID:1385928 PMID:8855299 RGD:11522760 RGD:8551846 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:serum (rat)
associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)		 RGD PMID:19449282 PMID:21396682 PMID:22227956 RGD:2307179 RGD:5147765 RGD:6893482 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO mRNA, protein:increased expression:blood (human) RGD PMID:17982103 RGD:36049802 NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle RGD PMID:21206533 RGD:6483008 NCBI chr10:112,748,283...112,812,368 JBrowse link
G ITGA2B integrin subunit alpha 2b ISO RGD PMID:15280099 RGD:2316360 NCBI chr16:62,001,082...62,019,470
Ensembl chr16:62,001,352...62,019,289 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:15280099 RGD:2316360 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 ISO RGD PMID:22609006 RGD:6892951 NCBI chr 6:9,515,789...9,526,699
Ensembl chr 6:9,515,416...9,522,797 		JBrowse link
G LBP lipopolysaccharide binding protein treatment ISO mRNA:increased expression:hepatocyte RGD PMID:8418776 PMID:8593028 PMID:16307218 RGD:9685191 RGD:9685193 RGD:9685196 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G LCN2 lipocalin 2 ISO mRNA:increased expression:brain,liver RGD PMID:21943033 RGD:126779582 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
G LOC103221104 cystathionine beta-synthase severity ISO mRNA:increased expression:liver (rat)
Protein:increased expression:spleen, lung (mouse)		 RGD PMID:16100527 PMID:24702258 PMID:27748832 RGD:40903019 RGD:40903035 RGD:40903049 NCBI chr 2:86,905,104...86,933,780 JBrowse link
G LOC103231478 myosin-6 ISO RGD PMID:7874842 RGD:12792976 NCBI chr29:23,753,251...23,780,822
Ensembl chr29:23,753,309...23,778,107 		JBrowse link
G LOC103231480 myosin-7 ISO RGD PMID:7874842 RGD:12792976 NCBI chr29:23,783,610...23,804,981
Ensembl chr29:23,783,557...23,799,771 		JBrowse link
G LOC103233058 fractalkine ISO protein:increased expression:atrium endocardium RGD PMID:19282612 RGD:4891965 NCBI chr 5:43,310,711...43,323,533
Ensembl chr 5:43,310,753...43,323,529 		JBrowse link
G LOC103233689 thromboxane A2 receptor ISO RGD PMID:2580129 PMID:15647606 RGD:11059531 RGD:1601450 NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B ISO protein:decreased tyrosine phosphorylation:liver RGD PMID:17327369 RGD:1601383 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G MAP2 microtubule associated protein 2 ISO mRNA, protein:decreased expression:neuron RGD PMID:21421895 RGD:6483086 NCBI chr10:95,319,649...95,431,106
Ensembl chr10:95,349,157...95,431,320 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 treatment ISO protein:increased activity:small intestine mucosa RGD PMID:21641970 PMID:24312512 RGD:10047418 RGD:5135029 NCBI chr17:36,012,164...36,095,542
Ensembl chr17:36,014,454...36,095,138 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO protein:increased phophorylation:hippocampus (rat) RGD PMID:12207162 RGD:150340687 NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425 		JBrowse link
G MC4R melanocortin 4 receptor ISO mRNA:increased expression:paraventricular nucleus (rat) RGD PMID:21343543 RGD:6484214 NCBI chr18:19,380,054...19,386,412
Ensembl chr18:19,380,849...19,381,847 		JBrowse link
G MIF macrophage migration inhibitory factor ISO protein:increased expression:plasma RGD PMID:16601957 RGD:1641983 NCBI chr19:7,000,837...7,001,700
Ensembl chr19:7,000,793...7,001,757 		JBrowse link
G MME membrane metalloendopeptidase severity ISO RGD PMID:11078421 RGD:13801040 NCBI chr15:35,577,460...35,681,730
Ensembl chr15:35,580,714...35,633,914 		JBrowse link
G MMP3 matrix metallopeptidase 3 ISO RGD PMID:17083784 RGD:2290426 NCBI chr 1:94,216,156...94,224,437
Ensembl chr 1:94,216,173...94,224,264 		JBrowse link
G MT3 metallothionein 3 ISO RGD PMID:12135776 RGD:10412330 NCBI chr 5:42,502,306...42,504,467 JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:19099858 RGD:7349370 NCBI chr 1:893,554...926,854 JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:26646455 RGD:42722616 NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339 		JBrowse link
G NFKBIA NFKB inhibitor alpha treatment
exacerbates		 ISO RGD PMID:10229101 PMID:19098124 RGD:126908017 RGD:126928139 NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA, protein:increased expression:intestine
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12620498 PMID:16787348 PMID:20519137 RGD:4891470 RGD:5147779 NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO protein:increased expression:aorta (rat) RGD PMID:10462376 RGD:7794732 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NPY neuropeptide Y treatment ISO RGD PMID:15342191 RGD:1580787 NCBI chr21:34,068,533...34,076,205
Ensembl chr21:34,068,530...34,075,127 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:15640646 RGD:4892561 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G OTC ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr  X:35,494,334...35,570,923
Ensembl chr  X:35,494,287...35,570,845 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 ISO RGD PMID:12217886 PMID:19268478 RGD:10427879 RGD:625688 NCBI chr 2:6,550,806...6,556,499
Ensembl chr 2:6,549,652...6,556,478 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial ISO mRNA,protein:decreased expression,decreased activity:liver: RGD PMID:19268478 RGD:10427879 NCBI chr24:1,077,206...1,087,306
Ensembl chr24:1,077,447...1,087,607 		JBrowse link
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:16337011 RGD:6483567 NCBI chr 4:90,246,413...90,289,148
Ensembl chr 4:90,248,598...90,289,089 		JBrowse link
G PCSK2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:16337011 RGD:6483567 NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22119535 RGD:6771174 NCBI chr16:56,863,763...56,947,479
Ensembl chr16:56,880,934...56,950,999 		JBrowse link
G PGF placental growth factor ISO protein:increased expression:multiple RGD PMID:16702604 RGD:6483601 NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989 		JBrowse link
G PLA2G7 phospholipase A2 group VII ISO protein:increased expression: : RGD PMID:10748027 RGD:7248791 NCBI chr17:25,538,645...25,571,230
Ensembl chr17:25,538,438...25,574,269 		JBrowse link
G PLAT plasminogen activator, tissue type treatment ISO RGD PMID:9091588 RGD:11541073 NCBI chr 8:40,164,391...40,196,627
Ensembl chr 8:40,163,891...40,196,555 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:increased expression:small intestine mucosa RGD PMID:21641970 RGD:5135029 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO mRNA:decreased expression:epididymal fat pad RGD PMID:20421294 RGD:6484543 NCBI chr 4:39,516,307...39,553,627 JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:liver, mitochondrion (mouse) RGD PMID:28615325 RGD:13432559 NCBI chr13:88,856,056...90,329,379 JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:18205901 PMID:23170801 RGD:11100030 RGD:11100034 NCBI chr10:2,789,227...2,799,783
Ensembl chr10:2,789,277...2,799,531 		JBrowse link
G PTAFR platelet activating factor receptor treatment ISO RGD PMID:2178565 RGD:10041063 NCBI chr20:104,627,591...104,658,840
Ensembl chr20:104,657,179...104,658,207 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat) RGD PMID:11058222 RGD:10043329 NCBI chr 4:39,440,697...39,453,983
Ensembl chr 4:39,440,276...39,454,004 		JBrowse link
G PTGIS prostaglandin I2 synthase treatment ISO RGD PMID:11076704 RGD:401960076 NCBI chr 2:14,420,318...14,484,667
Ensembl chr 2:14,441,983...14,488,264 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:21641970 RGD:5135029 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G REN renin ISO protein:increased activity:blood plasma (rat)
protein:increased activity:blood plasma (mouse)		 RGD PMID:16512638 PMID:30027346 RGD:125097481 RGD:125097499 NCBI chr25:25,159,816...25,193,620
Ensembl chr25:25,183,037...25,193,420 		JBrowse link
G SERPINC1 serpin family C member 1 treatment ISO RGD PMID:15995859 PMID:16457847 PMID:20519137 PMID:21396682 RGD:1599326 RGD:1599332 RGD:5147765 RGD:5147779 NCBI chr25:55,271,823...55,289,855 JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:21396682 PMID:25396762 RGD:10449434 RGD:5147765 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SERPINF1 serpin family F member 1 ISO protein:increased expression:plasma (human) RGD PMID:12386642 RGD:36174005 NCBI chr16:1,408,453...1,424,197 JBrowse link
G SERPING1 serpin family G member 1 treatment ISO RGD PMID:18652771 RGD:8661643 NCBI chr 1:15,617,122...15,634,540
Ensembl chr 1:15,616,674...15,633,855 		JBrowse link
G SLC18A3 solute carrier family 18 member A3 ISO protein:decreased expression:parietal cortex RGD PMID:17306796 RGD:5686693 NCBI chr 9:42,216,187...42,219,665
Ensembl chr 9:42,216,568...42,218,166 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 treatment ISO RGD PMID:18313662 RGD:7243881 NCBI chr13:87,744,600...87,780,846
Ensembl chr13:87,745,023...87,781,073 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 treatment ISO RGD PMID:18313662 RGD:7243881 NCBI chr13:87,835,077...87,881,410
Ensembl chr13:87,833,430...87,881,081 		JBrowse link
G SLC38A3 solute carrier family 38 member 3 ISO RGD PMID:20036385 RGD:9999227 NCBI chr22:11,591,680...11,606,291
Ensembl chr22:11,591,717...11,606,355 		JBrowse link
G SLC38A5 solute carrier family 38 member 5 ISO RGD PMID:20036385 RGD:9999227 NCBI chr  X:45,588,992...45,598,771 JBrowse link
G SLC7A5 solute carrier family 7 member 5 ISO RGD PMID:26337286 RGD:151361133 NCBI chr 5:73,229,953...73,269,801
Ensembl chr 5:73,229,951...73,269,754 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor ISO RGD PMID:25466948 RGD:9999425 NCBI chr 2:18,579,549...18,581,897
Ensembl chr 2:18,579,515...18,582,076 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:liver, skeletal muscle RGD PMID:15169905 RGD:2298923 NCBI chr 5:10,731,866...10,733,745
Ensembl chr 5:10,732,350...10,732,991 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:liver, skeletal muscle RGD PMID:12217886 PMID:15169905 RGD:2298923 RGD:625688 NCBI chr16:70,353,099...70,356,401
Ensembl chr16:70,354,746...70,355,423 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16741687 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974 		JBrowse link
G SPARC secreted protein acidic and cysteine rich ISO mRNA, protein:decreased expression:kidney RGD PMID:10703670 RGD:2300026 NCBI chr23:54,224,003...54,248,869
Ensembl chr23:54,222,838...54,238,006 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO RGD PMID:15647606 RGD:1601450 NCBI chr21:108,584,458...108,779,357
Ensembl chr21:108,628,570...108,779,163 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr 7:102,467,075...102,485,434
Ensembl chr 7:102,467,640...102,485,394 		JBrowse link
G TFPI tissue factor pathway inhibitor treatment ISO RGD PMID:17537762 RGD:11062086 NCBI chr10:73,004,762...73,105,772
Ensembl chr10:73,002,522...73,105,858 		JBrowse link
G THBD thrombomodulin ISO mRNA:decreased expression:endothelial cell RGD PMID:12611420 PMID:19487933 PMID:20348393 RGD:1601652 RGD:5684988 RGD:5685037 NCBI chr 2:52,041,950...52,045,946
Ensembl chr 2:52,043,746...52,045,626 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:17083784 RGD:2290426 NCBI chr19:15,621,609...15,684,118
Ensembl chr19:15,622,431...15,680,449 		JBrowse link
G TLR2 toll like receptor 2 treatment ISO RGD PMID:22172266 RGD:7241094 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 treatment
disease_progression		 ISO mRNA:increased expression:liver: RGD PMID:22172266 PMID:23977376 RGD:14697731 RGD:7241094 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TNF tumor necrosis factor treatment ISO protein:increased expression:plasma (rat)
associated with liver cirrhosis
XCO:0000822 JTE-607		 RGD PMID:8283134 PMID:10493164 PMID:12813371 PMID:15242491 PMID:17324147 More... RGD:14995427 RGD:14995443 RGD:15023464 RGD:38501090 RGD:40903016 RGD:4891465 RGD:5147765 RGD:5147779
G TREM1 triggering receptor expressed on myeloid cells 1 treatment ISO RGD PMID:15585833 PMID:21507332 RGD:126925982 RGD:126928122 NCBI chr17:30,873,647...30,885,292
Ensembl chr17:30,873,666...30,886,967 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO mRNA:increased expression:brain: RGD PMID:20061033 RGD:7240511 NCBI chr20:32,616,425...32,635,903
Ensembl chr20:32,615,333...32,635,862 		JBrowse link
G VWF von Willebrand factor ISO protein:increased expression:endothelial cell: RGD PMID:2650559 RGD:11079230 NCBI chr11:5,994,499...6,176,949
Ensembl chr11:5,994,039...6,162,260 		JBrowse link
endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCH1 GTP cyclohydrolase 1 treatment ISO RGD PMID:8602831 RGD:329961578 NCBI chr24:32,029,997...32,079,656
Ensembl chr24:32,027,648...32,079,490 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A treatment ISO RGD PMID:19318092 RGD:401901206 NCBI chr 3:24,820,029...24,884,472
Ensembl chr 3:24,820,035...24,883,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15273
    disease by infectious agent 2055
      Bacterial Infections and Mycoses 979
        bacterial infectious disease 785
          Bacteremia 165
            Endotoxemia + 150
            Flavimonas Oryzihabitans Bacteremia 0
            Hemorrhagic Septicemia 0
            pneumococcal bacteremia 0
Path 2
Term Annotations click to browse term
  disease 15273
    Pathological Conditions, Signs and Symptoms 11780
      Pathologic Processes 7295
        Shock 388
          Systemic Inflammatory Response Syndrome 369
            Sepsis 367
              bacterial sepsis 165
                Bacteremia 165
                  Endotoxemia + 150
                  Flavimonas Oryzihabitans Bacteremia 0
                  Hemorrhagic Septicemia 0
                  pneumococcal bacteremia 0
paths to the root